The findings were published in the Dec. 2, 2005 issue of Science.

     Although the stem cell niche — the microenvironment surrounding a stem cell — and its associated signals are known to be important for controlling stem cell populations, it remains largely unclear how these signals are interpreted by the stem cell at the level of gene expression.

     Chromatin remodeling factors are important for controlling gene expression by modulating the chromatin structure in which an individual gene is buried. In this study, Dr. Xie’s team identified two chromatin remodeling factors — ISWI and Domino. Each is involved in controlling self-renewal and proliferation of stem cell populations. This study also shows that different stem cell populations require different chromatin factors to help interpret the signals sent by niches.

     “I believe that we must truly understand fundamental aspects of stem cell regulation in tissues before we are able to harness their full power in regenerative medicine,” said Dr. Xie. “This work contributes to the fundamental understanding of stem cell regulation. The information gained from this kind of study will enhance our ability to use stem cells in future therapeutic applications.”

     “Dr. Xie’s team has identified chromatin remodeling factors as important components in allowing stem cells to translate and interpret signals from their niche,” said Robb Krumlauf, Ph.D., Scientific Director. “Correct interpretation of the niche signals is an essential step in regulating stem cell renewal and controlling their proliferation.”

     More information about Dr. Xie’s lab group can be found at http://www.stowers-institute.org/labs/XieLab.asp.

About the Stowers Institute
     Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.