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Stowers Lecture Series 2000-2004

Stowers Lecture Series 2000-2007

 

November 8, 2000       Richard Klausner (National Institutes of Health, National Cancer Institute)

 

November 29, 2000    Doug Cyr (University of Alabama at Birmingham)

Roles for Hsp70 in CFTR Folding and Proteosomal Degradation

 

December 4, 2000       Paul Trainor (National Institute for Medical Research, London)

Craniofacial Development:  The Role of Neural Crest and Hox Gene Plasticity

 

January 10, 2001          Brian Sauer (Oklahoma Medical Research Foundation)

Cre Recombinase and Mouse Genetics by Design

 

January 24, 2001          Charles Little (University of Kansas Medical Center)

Vasculogenesis: Formation of the First Blood Vessels

 

January 31, 2001          Glen Andrews (University of Kansas Medical Center)

Mechanisms of Regulation of Gene Expression by Zinc

 

February 7, 2001         Jeff Price (University of Missouri - Kansas City)

Doubletime: A Protein Kinase that Establishes the Molecular Oscillations of Circadian Rhythms

  

February 14, 2001       Skip Garner (University of Texas Southwestern Medical Center at Dallas)

Informatics and Instrumentation for the Post-genome Era

 

February 21, 2001       Jill Pelling (University of Kansas Medical Center)

Molecular Mechanism of Chemoprevention by the Bioflavonoid Apigenin:  Post-translational Stabilization of the p53 Tumor Suppressor Protein

 

February 28, 2001       S. K. Dey (University of Kansas Medical Center)

Molecular Signaling in Embryo-Uterine Interactions During Implantation

 

March 7, 2001             Brian Livingston (University of Missouri - Kansas City)

Regulation of Transcription during Endoderm Development in Sea Urchins

 

March 14, 2001           Edward (Ward) Wakeland (University of Texas Southwestern Medical Center at Dallas)

Mouse Genetics in the Context of a Mouse Model of SLE

 

March 21, 2001           Alan Godwin (University of Kansas Medical Center)

                                    Hoxc 13:  Hair Today, Gone Tomorrow

 

March 28, 2001           Kelley Thomas (University of Kansas Medical Center)

Mutation Accumulation in the c.Elegans Genome

 

April 11, 2001              Barry Festoff (University of Kansas Medical Center)

Conformational Neurodegenerative Diseases:  Role of Proteases and Transglutaminases in Model Systems

 

May 2, 2001                Luis Parada (University of Texas Southwestern Medical Center at Dallas)

Neurotrophin Ligands and their Receptors in the Survival of Early Neurons

 

May 9, 2001                Bruce Lahn (University of Chicago, Howard Hughes Medical Institute)

Comparative Genomics:  A New Tool for Studying Genome Function and Evolution

 

May 16, 2001              Randy Johnson (University of Texas, MD Anderson Cancer Center)

Vertebrate Segmentation and Pattern Formation

 

May 30, 2001              Thom Kaufman (Indiana University, Howard Hughes Medical Institute)

Hox Genes and the Arthopodan Bauplan

 

June 6, 2001                Alfred G. Gilman (University of Texas Southwestern Medical Center at Dallas)

                                   

September 5, 2001       Alan Spradling (Carnegie Institute)

Regulation of Cell Differentiation During Early Stages of Drosophila Oogenesis

 

September 19, 2001    Stephen Alexander (University of Missouri - Columbia)

Proteomic and Genetic Approaches to studies of Regulated Protein Secretion to Anticancer Drugs 

 

September 26, 2001    Thomas O’Halloran (Northwestern University)

                                    Chemical Biology of Intracellular Transition Metals in Human Disease      

 

October 3, 2001          Kevin Moore (Oklahoma Medical Research Foundation)

                                    Biochemistry of Leukocyte-Endothelial Interactions             

 

October 10, 2001        Beth Sullivan (The Salk Institute)

                                    Structure and Function of Centromeric Chromatin in Flies and Humans    

 

October 17, 2001        Donald Riddle (University of Missouri - Columbia)

                                    Genetics of Development and Longevity in C. elegans          

 

October 24, 2001        Ed Ziff (New York University School of Medicine)

                                    Regulating the Strength of Synapses through Trafficking of Glutamate Receptors 

 

November 7, 2001       Robert Haley (University of Texas Southwestern Medical Center at Dallas)

                                    Gulf War Syndrome:  A Toxic Cellular Inquiry to Deep Brain Structures    

 

November 14, 2001     Nancy Bonini (University of Pennsylvania, Howard Hughes Medical Institute)

                                    Drosophila as a Model for Human Neurodegenerative Disease         

 

November 28, 2001     Ali Shilatifard (St. Louis University School of Medicine)

COMPASS:  A SET Domain Containing Trithorax Related Complex Involved in Transcriptional Regulation and Oncogenesis

 

December 5, 2001       Stan Fields (University of Washington, Howard Hughes Medical Institute)

Using Yeast to Analyze the Interactions of Proteins, Nucleic Acids and Small Molecules                            

 

December 12, 2001     Joshua Sanes (Washington University)

Synapse Formation Analyzed in Fluorescent and Mutant Mice

 

January 9, 2002            Rick Young (Massachusetts Institute of Technology, Whitehead Institute)

Mapping Genome Regulatory Circuitry

 

January 16, 2002          Scott Saunders (Washington University)

Heparan Sulfate Proteoglycans:  Master Regulators of Cellular Responsiveness to Growth Factors and Morphogens

 

January 23, 2002          Gary Stormo (Washington University)

Experimental and Computational Methods for Identifying Regulatory Sites in DNA Sequences

 

February 6, 2002         David Ornitz (Washington University) 

FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease

 

February 13, 2002       Joseph Goldstein and Michael Brown (University of Texas Southwestern Medical Center at Dallas)

How Cells Control Cholesterol

 

February 20, 2002       Robert G. Roeder (The Rockefeller University)

Regulation of Transcription in Animal Cells through the Action of Diverse Coactivators

 

February 27, 2002       Jeffrey Milbrandt (Washington University)

Development, Regeneration and Tumorigenesis:  Mechanistic Insights from Gene Targeting and Expression Profiling

 

March 6, 2002             Pamela Geyer (University of Iowa)

Insulators:  A New Class of Elements that Establish Independent Domains of Gene Function

 

March 13, 2002           Mark Noble (University of Rochester, New York)

Pivotal Roles of Redox Regulation in Precursor Cell Function and Neoplasia

 

March 20, 2002           Steve Johnson (Washington University)

How the Zebrafish Gets its Stripes

 

March 27, 2002           John Heuser (Washington University)

The Ultrastructural Basis of Cancer Cell Invasiveness

 

April 3, 2002                Eric Olson (University of Texas Southwestern Medical Center at Dallas)

Transcriptional Control of Heart Development and Disease

 

April 10, 2002              Bill Skarnes (University of California-Berkeley)

Functional Analysis of the Mammalian Genome

 

April 17, 2002              Paul Kelly (University of Kansas)

Signaling Pathways that Regulate Synaptic Transmission in Brain

  

April 24, 2002              Margaret Baron (New York University)

Programming the Embryo to Make Blood and Vascular Endothelial Cells

 

May 1, 2002                Jiyan Ma (University of Chicago)

Exploring the Cellular Mechanism of Prion Disease:  Misfolding and Retrograde Transport of PrP Generates a Neurotoxic PrPSc-like Conformation

 

May 8, 2002                Andy McMahon (Harvard University)

Hedgehog Signaling in the Vertebrate Embryo

 

May 15, 2002              Jerry Workman (Pennsylvania State University, Howard Hughes Medical Institute)

Functions and Interactions of Histone Acetyltransferase Complexes and the SWI/SNF Complex in Yeast

 

May 22, 2002              Bill McGinnis (University of California, San Diego)

Hox Protein Mutation and Macroevolution of the Insect Body Plan

 

May 29, 2002              Natalie Ahn (University of Colorado at Boulder)

New Avenues in MAP Kinase Signal Transduction

 

September 4, 2002       Yi Rao (Washington University)
Signal Transduction Mechanisms Guiding Cell Migration in the Nervous System

 

September 11, 2002     Mary Faith Marshall (University of Kansas Medical Center)
Demagoguery, Ideology, and Rhetoric: The Politics of Stem Cell Research

 

September 18, 2002     Helen Hobbs (University of Texas Southwestern Medical Center at Dallas)
Genetic Defenses Against Sterol Accumulation

 

September 25, 2002     Marianne Bronner-Fraser (California Institute of Technology)
Induction of the Neural Crest

 

October 2, 2002          Michael Rosbash (Brandeis University, Howard Hughes Medical Institute)
Connections Between Transcription and RNA Processing

 

October 9, 2002          Tom Petes (University of North Carolina)
Genetic Regulation of Genome Stability in Yeast

 

October 16, 2002        Norbert Perrimon (Harvard Medical School, Howard Hughes Medical Institute)
Functional Genomics in Drosophila: Highthroughput RNAi Screens in Drosophila Cells

 

October 23, 2002        Ian Willis (Albert Einstein College of Medicine)
Activation and Repression of Transcription by RNA Polymerase III

 

October 30, 2002        Kees Weijer (Wellcome Trust Biocentre, University of Dundee)
Chemotaxis and its Role in Gastrulation in the Chick

 

November 6, 2002       Oliver Hobert (Columbia University)
Axonal Organization in the Nervous System Relies on a Dedicated Maintenance Mechanism

 

November 13, 2002     Thomas Sudhof (University of Texas Southwestern Medical Center at Dallas)
Ca2+ Regulation of Synapse Function

 

November 20, 2002     Ken Peterson (University of Kansas Medical Center)
Molecular Control of Human ß-globin Gene Switching

 

December 4, 2002       Ting Xie (Stowers Institute for Medical Research)
Genetic and Molecular Studies on Stem Cell Regulation in Drosophila

 

December 11, 2002     Ross Cagan (Washington University)
Viewing Programmed Cell Death and Oncogenesis through the Eye of a Fly

 

January 8, 2003            Jim Haber (Brandeis University)
Exploring Chromosome Structure by Studying Recombination

 

January 15, 2003          Nahum Sonenberg (McGill University, Canada)
Ribosome Recruitment in Eukaryotes: Regulation of Gene Expression and Cell Growth

 

January 22, 2003          Steven Henikoff (Fred Hutchinson Cancer Research Center)
Evolution and Dynamics of Variant H3 Histones

 

January 29, 2003          Jeff Lichtman (Washington University)
Monitoring Synapses in Living Animals

 

February 5, 2003         Trudi Schupbach (Princeton University, Howard Hughes Medical Institute)
The Control of Signaling through the EGF Receptor in Drosophila Oogenesis

 

February 12, 2003       R. Sanders Williams (Duke University)
Calcium-regulated Signaling Pathways Control Cellular Mass, Mitochondrial Biogenesis and Gene Expression in Cardiac and Skeletal Myocytes

 

February 19, 2003       Joseph Takahashi (Northwestern University)
Forward Genetics in the Mouse: Gene Discovery and Functional Analysis of Circadian and Brain Pathways

 

February 26, 2003       Margaret Goodell (Baylor College of Medicine)
Mammary, Muscle, and Bone Marrow Stem Cells - Biology and Potential Plasticity

 

March 4, 2003             Monica Justice (Baylor College of Medicine)
Mouse Mutagenesis:  Defining Gene Function and Modeling Human Disease

 

March 12, 2003           Malcolm Whitman (Harvard Medical School)
Regulation and Function of TGFß Signals during early Embryonic Patterning

 

March 19, 2003           Minx Fuller (Stanford University)
Life's a Niche: Regulation Stem Cell Self-Renewal and Differentiation

 

March 26, 2003           Robert Cohen (University of Kansas)
Polarization of the Drosophila Oocyte

 

April 2, 2003                Marty Chalfie (Columbia University)
A Molecular Model for Mechanosensation in C. elegans

 

April 9, 2003                Susan Lindquist (Whitehead Institute)
Prions: How Strange Diseases and Strange Genetics Produce New Paradigms in Biology

 

April 16, 2003              Steve McKnight (University of Texas Southwestern Medical Center at Dallas)
Reciprocal Coupling of Metabolism and Circadian Rhythm

 

April 23, 2003              Ruth Lehmann (Skirball Institute, New York University)
Germ Line Stem Cell Development in Drosophila

  

May 7, 2003                Winship Herr (Cold Spring Harbor Laboratory)
Combinatorial Mechanisms of Transcriptional Regulation in Human Cells

 

May 14, 2003              Doug Koshland (Carnegie Institution of Washington)
Chromosome Folding and Genome Stability

 

May 21, 2003              Nancy Jenkins (National Cancer Institute)
A Genetic Approach to the Study of Vesicle Transport in the Mouse

 

May 22, 2003              Neal Copeland (National Cancer Institute)
Retroviral Tagging Provides a Potent Cancer Gene Discovery Tool in the Post-genome Era

 

May 28, 2003              Mark Krasnow (Stanford University)
Genetic Dissection of Branching Morphogenesis

 

September 3, 2003       Christopher Burge (Massachusetts Institute of Technology)

                                    Bioinformatics of MicroRNAs

 

September 10, 2003     Nouria Hernandez (Cold Spring Harbor Laboratory, Howard Hughes Medical Institute)

                                    CK2 Regulation of Human RNA Polymerase III Transcription in a Well-Defined in vitro Transcription System

 

September 17, 2003     Philip Needleman (Washington University)

                                    COX2 Inhibitors:  From Discovery to Inflammation and Cancer

 

September 24, 2003     Christopher Wylie (Cincinnati Children’s Hospital Research Foundation)

                                    Germ Cells

 

September 25, 2003     Janet Heasman (Cincinnati Children’s Hospital Medical Center)        

                                    What my Mother Told Me:  Maternal Control of Early Xenopus Development

 

October 1, 2003          Elizabeth Robertson (Harvard University)

                                    Making Heads and Tails of the Early Embryo:  TGFb Pathways Regulating Axis Formation in the Mouse

 

October 15, 2003        David Ish-Horowicz (Cancer Research UK)

                                    Taking the A(pical) Train:  Mechanisms and Specificity of RNA Trafficking in Drosophila

 

October 29, 2003        Kerry Bloom (University of North Carolina)

                                    Mechanisms of Chromosome Segregation

 

November 5, 2003       Janet Rossant (Mount Sinai Hospital, University of Toronto)

                                    Stem Cells and Developmental Pathways in the Early Mouse Embryo

 

November 12, 2003     Thomas Jessell (Columbia University)

                                    Control of Motor Neuron Identity and Connectivity

 

November 19, 2003     David Wilkinson (National Institute for Medical Research, London)

                                    Formation and Function of Boundaries in Hindbrain Patterning

 

December 3, 2003       Gail Martin (University of California)

                                    Genetic Analysis of FGF Function in Mammalian Embryogenesis

 

December 10, 2003     Brigid Hogan (Duke University)

                                    Epithelial-Mesenchymal Cell Interactions and Branching Morphogenesis:  The Mouse Lung as a Model System

 

January 7, 2004            Gary Schoenwolf (University of Utah)

                                    Endoderm as a Source of Patterning Information for Early Chick Embryogenesis

 

January 14, 2004          Marian Carlson (Columbia University)

                                    Regulation of Snf1/AMPK Kinases and Responses to Metabolic Stress

 

January 21, 2004          Claudio Stern (University College, London)

                                    How to Make a Brain:  Molecular Dissection of Neural Induction

 

January 28, 2004          Anton Berns (Netherlands Cancer Institute)

                                    Mouse Models for Cancer

 

February 4, 2004         Nahum Sonenberg (McGill University)

                                    Ribosome Recruitment in Eukaryotes:  Regulation of Gene Expression and Cell Growth

 

February 11, 2004       Sean Carroll (University of Wisconsin-Madison)

                                    Molecular Genetics of Animal Evolution

 

February 18, 2004       David Lohnes (Clinical Research Institute of Montreal)

                                    Regulation of Cdx1 by Retinoid and wnt Signaling Pathways

 

February 25, 2004       Linheng Li (Stowers Institute for Medical Research)

                                    BMP Signaling and Adult Stem Cell Development

 

March 3, 2004             Anne Brunet (Children’s Hospital, Harvard University)

                                    The Forkhead Transcription Factors in the Control of Apoptosis, Resistance to Stress, and Organismal Longevity

 

March 10, 2004           Alexander Joyner (Skirball Institute, Howard Hughes Medical Institute)

                                    Organizing Centers and Compartments Pattern the Nervous System

 

March 17, 2004           Elaine Fuchs (Rockefeller University)

                                    Beauty is Skin Deep:  The Biology of the Epidermis and Hair Follicles

 

March 24, 2004           Bob Kingston (Harvard University)

                                    Functional Analysis of Complexes that Regulate Chromatin Structure and Transcriptional Memory

 

March 31, 2004           Lee Niswander (Sloan-Kettering Institute, Howard Hughes Medical Institute)

                                    Understanding Vertebrate Limb and Neural Development Using a Multifaceted Approach

 

April 7, 2004                Haringer Singh (University of Chicago, Howard Hughes Medical Institute)

                                    Transcriptional Regulation of Cell Fates and Gene Expression in the Immune System

 

April 21, 2004              David Anderson (California Institute of Technology)

                                    Molecular Control of Stem Cell Fate Determination in the Central and Peripheral Nervous System

 

April 28, 2004              Richard Mann (Columbia University)

                                    The Control of Hox Specificity:  New Cofactors Among Old Friends

 

May 12, 2004              Judith Kimble (University of Wisconsin-Madison, Howard Hughes Medical Institute)

                                    Controls of Germline Stem Cells in C. elegans

 

May 19, 2004              Phil Soriano (Fred Hutchinson Cancer Research Center)

                                    Defining the Signaling Specificity of Receptor Tyrosine Kinase Signaling

 

May 26, 2004              Jim Smith (University of Cambridge)

                                    Making Mesoderm in the Frog

 

June 2, 2004                John Reed (Burnham Institute)

                                    Apoptosis Mechanisms

 

September 8, 2004       Xiaodong Wang (University of Texas Southwestern Medical Center at Dallas, Howard Hughes Medical Center)
Biochemical Studies of Apoptosis

 

September 22, 2004     Frank Costantini (Columbia University)

                                    The Role of GDNF/Ret Signaling in Branching Morphogenesis during Kidney Development

 

September 29, 2004     Robert Lehman (Stanford University)

                                    DNA Replication and Latency in Herpes Viruses

 

October 6, 2004          Tony Gorry (Rice University)

                                    Information Technology and Behavior

 

October 13, 2004        Virginia Papaioannou (Columbia University)

                                    T-Box Genes in Mouse Development

 

October 20, 2004        Ray Gesteland (University of Utah)

                                    Recoding:  Programmed Changes in Decoding

 

October 27, 2004        David Albertini (University of Kansas Medical Center)

                                    Maternal Governance of Embryogenesis in Mammals:  Genetic Models of the Signaling Interface between Germ Line and Soma

 

November 3, 2004       Richard Hanson (Case Western Reserve University)

                                    Glyceroneogenesis Revisited

 

November 10, 2004     Roy Jensen (University of Kansas Medical Center)

                                    Molecular Analysis of Breast Neoplasia

 

November 17, 2004     Tom Gridley (The Jackson Laboratory)

                                    Notch Signaling in Mice

 

December 1, 2004       Alan Hinnebusch (National Institutes of Health)

                                    Recruitment and Function of Cofactors in Transcriptional Activation by GCN4

 

December 8, 2004       Michael Shen (University of Medicine and Dentistry of New Jersey)

                                    Regulation of Nodal Signaling in Mouse Embryogenesis

 

January 12, 2005          Cliff Tabin (Harvard Medical School, Howard Hughes Medical Institute)

                                    Signals Patterning the Developing Limb

 

January 19, 2005          John McDonald (Kennedy Krieger Institute)

                                    Repairing the Damaged Cord:  From Stem Cell to Activity-based Mechanisms of Recovery

 

February 2, 2005         Larry Simpson (University of California-Los Angeles, Howard Hughes Medical Institute)

                                    A Complex Business:  Uridine Insertion/Deletion RNA Editing in Trypanosome Mitochondria

 

February 9, 2005         Robin Lovell-Badge (National Institute for Medical Research)

                                    How are the Differences Between Males and Females Initiated During Mammalian Development

 

February 16, 2005       Mark Henkemeyer (University of Texas Southwestern Medical Center at Dallas)

                                    Ephrin Signaling

 

February 23, 2005       Drew Noden (Cornell University)

                                    Head Mesoderm-Neural Crest Interactions:  A Story of Victims and Bullies?

 

March 2, 2005             Bruce Hay (California Institute of Technology)

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